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KMID : 1094720180230050532
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Biotechnology and Bioprocess Engineering
2018 Volume.23 No. 5 p.532 ~ p.540
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Kinetics and Mechanism of Ultrasound-assisted Extraction of Paclitaxel from Taxus chinensis
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Yoo Kyung-Wan
Kim Jin-Hyun
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Abstract
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Batch experimental studies were carried out for the ultrasound-assisted extraction of paclitaxel from Taxus chinensis while varying parameters such as ultrasound power, extraction temperature and contact time. The extraction of the majority of the paclitaxel (~99%) was achieved from the biomass by a single extraction at 380W of ultrasound power for a period of 10 min. The kinetics data obtained for the paclitaxel extractions, and the dominant role played by intraparticle diffusion, were found to be in concordance with the pseudo-second-order model, and the intraparticle diffusion model respectively. The effective diffusion coefficient of paclitaxel (4.1882 × 10-13 ~ 5.7093 × 10-13 m2/s) and the mass transfer coefficient (4.705 × 10-8 ~ 14.1160 × 10-8 m/s) increased when the extraction temperature and ultrasound power were raised.
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KEYWORD
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paclitaxel, ultrasound-assisted extraction, kinetics, effective diffusion coefficient, mass transfer coefficient
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